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Groups 3: Colitis was induced and the rats treated with normal (recommended daily) dose of four vitamins (thiamin 2 mg/kg/d, riboflavin 1.5 mg/kg/d, pyridoxine 3 mg/kg/d, and cyanocobalamin 25 g/kg/d) concurrently 10 days before colitis induction and after that continued for 5 days.[15] Groups 4: Colitis was induced and the rats treated with mega (10 of normal) dose of four vitamins (thiamin 20 mg/kg/d, riboflavin 15 mg/kg/d, pyridoxine 30 mg/kg/d, and cyanocobalamin 250 g/kg/d) concurrently for 5 days started 2 h before colitis induction.[16] Groups 5: Colitis was induced and the rats treated with mega dose of vitamin B1 (20 mg/kg/d, i.p.) for 5 days started 2 h before UC induction