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The methodology for calculating the proposed CCR adjustment factor is discussed in the FY 2026 IPPS/LTCH PPS proposed rule (90 FR 18434 through 18435)

Initial assessment in rats with two ligations at the left colic artery and vein for 15 min (IC rats) and in rats that had two ligations at the left colic artery and vein for 15 min, and then were reperfused for the next 15 min (IC + RL rats) The surgery was conducted in deeply anesthetized rats

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Anecdotally reported side effects include transient headaches, mild lethargy, and injection site discomfort

Tension-type headaches: The most common type of headache, it generally feels like having a tight band around the skull