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Apremilast, a phosphodiesterase 4 inhibitor, offers a safer hepatic profile but has lower efficacy than traditional systemic agents

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182 In two subsequent studies, low-dose curcumin showed a non-significant trend toward lowering total cholesterol and LDL cholesterol in acute coronary patients, 183 while high dose-curcumin (14 grams/day) exhibited non-significant increases in total-, LDL-, and HDL cholesterol