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Only 30 minutes after head trauma the scientists noticed the presence of reactive oxygen species which cause cell death and DNA damage in the protective membrane surrounding the brain

4.3 Targeted therapeutic strategies in response to ERS It is well known that both the morphology of biomaterials and the UPR pathway can significantly affect the osteogenic differentiation of stem cells and controlling UPR-mediated osteogenic effects by modulating the surface morphology of biomaterials is expected to be an emerging therapeutic strategy (189, 190) ( Figure 2 )

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59 In a 28-day Phase IIIb trial (study 0149 [NCT03095456]), revefenacin and tiotropium (active control) effectively improved trough FEV 1 and FVC from baseline with improvement numerically favoring revefenacin versus tiotropium

Assumptions were made about the involvement of encephalitis [17, 18] and medications used in the treatment protocol of COVID-19 such as steroids, chloroquine derivatives, and benzodiazepines [19]