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Learning Objectives Examine the roles of chelation and luspatercept in managing iron overload in acquired sideroblastic anemias and MDS Evaluate the indication for iron chelation therapy and luspatercept treatment in patients with MDS-RS Understand the pathomechanism of systemic and mitochondrial iron overload in MDS with ring sideroblasts CLINICAL CASE A 69-year-old man, previously in good health, presents with anemia (hemoglobin 9.1 g/dL) and dyspnea on exertion

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Additionally, a meta-analysis of 46 randomized trials, including 171,244 participants, found that supplemental vitamin E, singly or in combination with other antioxidants, did not significantly alter the risk of all-cause mortality (126)

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The middle shelf of the refrigerator, toward the back, away from the door, in a dark container or wrapped in foil