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In 2023, Lopez-Otin proposed twelve markers of aging, including genomic instability, telomere loss, epigenetic changes, loss of protein balance, failure of macroautophagy, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell depletion, altered intercellular communication, chronic inflammation, and dysbiosis

Inoltre, sono stati riscontrati simili effetti benefici sulla funzione cerebrale generale delle persone anziane che non soffrivano di Alzheimer n di altre malattie cerebrali

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Magnesium, for example, is known to help decrease headaches, restlessness, muscle spasms during sleep, muscle pains and digestive discomfort