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RNA silencing operates through two major mechanism: (i) Post-transcriptional gene silencing (PTGS) where Si RNAs or miRNAs direct sequence- specific mRNA degradation or translational repression, and (ii) Transcriptional gene silencing (TGS), which operates through RNA-directed DNA methylation (RdDM), histone modifications and chromatin remodeling

In physician-supervised protocols, it is prescribed for cognitive decline support, neurological rehabilitation, and executive function enhancement

Myocardial ischemia constitutes the predominant mechanism underlying CHD pathophysiology and serves as the central pathological process

Sawka MN, Burke LM, Eichner ER, Maughan RJ, Montain SJ, Stachenfeld NS