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Sadeghianmaryan et al., 2020)

Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice

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2.4 Mediation of targeted therapy resistance Under the pressure of the selection of targeted drugs, tumor cells evade treatment through metabolic reprogramming ( Notably, this metabolic adaptation often coexists with and may be reinforced by the reactivation of oncogenic signaling pathways, which provide complementary survival signals under therapeutic pressure