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Many patients are prescribed opioids before consulting a spine surgeon, making them opioid-experienced and heightening the risk of misuse, abuse, and dependency.6 Additionally, substantial postoperative opioid needs are common7 because uncontrolled postoperative pain following spinal surgery is common and underscores the need for effective pain management strategies.8 A 2020 study by Yang et al revealed that 57% of patients experienced inadequate pain control within the first 24 hours after surgery.9 This inadequate pain control was defined by a mean numeric rating scale score of greater than 4

doi: 10.1038/s41392-022-01004-z 260 YangyunWGuoweiSShufenSJieYRuiYYuR

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In terms of molecular design, innovations in prodrug and linker engineering, including photo-responsive, enzyme-activated, folate-targeted, and reactive oxygen species (ROS)-triggered systems, achieve precise spatiotemporal regulation and controlled release of PROTAC activity

The FDA failed to recognize that studies of workers at chloralkali plants, where concomitant exposure to mercury vapor and chlorine gas occurs, are invalid for establishing reference exposures levels for non-occupational exposure to Hg