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Oxidatieve stress ontstaat wanneer de productie van vrije radicalen de capaciteit van het antioxidant systeem overtreft, wat leidt tot de schadelijke effecten van deze radicalen

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Using this approach, prodrug 17 was developed, which is likely why it displayed such excellent in vivo activity

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Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

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Loss of Parkinsons disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

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