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Statements Author contributions TH, SR-K, and SP drafted and edited the manuscript

Elastin and its degradation products have multiple roles in the oncologic process

The duration of the trial was one year with 416 patients exposed to Reclast administered once as a single 5 mg dose in 100 mL infused over 15 minutes, and 417 patients exposed to a commercially-available oral daily bisphosphonate (active control) for one year