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Nat Rev Mol Cell Biol 25(2):133155 Ru Q, Li Y, Chen L, Wu Y, Min J, Wang F (2024) Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Zhang Y, Ogbu D, Garrett S, Xia Y, Sun J

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Discussion Although ALS and FTD are highly heterogenous diseases, the nearly universal convergence on TDP-43 proteinopathy emphasizes a need to understand early drivers of this pathogenic process

This interaction supports coordinated regulation of energy metabolism, oxidative homeostasis, and membrane integrity through a division of labor in fatty acid -oxidation, balanced ROS production and scavenging, and membrane lipid synthesis and transport, including ether phospholipids