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According to previous studies by Park et al (121) and Lee et al (122), terrein, a novel fungal metabolite reduces TYR expression by downregulating MITF in a manner that is dependent on ERK activation, with its inhibitory effects on melanin synthesis prolonged by ubiquitin-mediated proteasomal degradation

153 With the help of the CD44 target and MS boost, M@H-NPs could penetrate bloodbrain tumor barrier (BTB), internalizing into brain metastatic tumor cells (BMTCs), blunting drug efflux at BMTCs, and producing effective treatment which can extend the median survival time in breast cancer brain metastases models

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Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy

The minocycline trial in fact even showed negative results for treated patients [64]