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[DOI] [PubMed] [Google Scholar] 17.Rubino F.M., Verduci C., Giampiccolo R., Pulvirenti S., Brambilla G., Colombi A

One peptide with 10 cysteine residues, the sequence of which mimics that of the -domain of MT, binds the nanoparticles and a mass spectrometric analysis of the peptide-bound nanoparticles shows that it binds three cadmium ions released from the surface

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Once inside the cell, the -glutamyl-amino acid can be metabolized to release the amino acid and 5-oxoproline, which can then be converted into glutamate to be used in the synthesis of GSH

Although such investigations are still in the preclinical stage, they are providing new directions for the treatment of PDAC