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Furthermore, we provide an overview of HIF-1-related drugsboth those approved and those still under clinical investigationwithin the context of the previously outlined regulatory mechanisms

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Changes in oxidative stress signaling in PD are further evidenced by the significant PD-associated decreased abundance of gamma-glutamylalanine (see Table 2), which is involved in the metabolism of glutathione, an antioxidant that is essential for cellular protection against oxidative damage 13

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GLP-1 medications work by mimicking the GLP-1 hormone, which slows gastric emptying, signals satiety to the brain, and helps regulate blood sugar