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Inflammatory mediators (e.g., lipopolysaccharide (LPS)-interleukin-6 (IL-6)), signaling pathways (e.g., programmed death-ligand 1 (PD-L1)-hypoxia-inducible factor 1 (HIF-1), nucleotide-binding oligomerization domain (NOD)-like receptor X1 (NLRX1)-tumor necrosis factor- (TNF-)), and IB degradation promote nuclear factor-B (NF-B) nuclear translocation and Yes-associated protein (YAP) phosphorylation, ultimately upregulating pro-apoptotic genes [33]

In addition, in aged mice, gavage of BS for 28 consecutive days further alleviated the senescence phenotype

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While collagen is safe for most people, there are a few exceptions