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Vitamin B12 is crucial for several physiological processes, including: Red blood cell formation deficiency leads to megaloblastic anaemia, characterised by large, immature red blood cells Neurological function B12 is required for myelin synthesis and nerve health DNA synthesis essential for cell division and growth Without adequate B12, patients may develop symptoms such as fatigue, pallor, shortness of breath, glossitis (sore tongue), paraesthesia (pins and needles), and in severe cases, neurological complications including peripheral neuropathy, ataxia, and cognitive impairment

Coronary artery disease in the Hurler syndrome

For the entire cohort, 22/64 (34.4%) achieved FHR

Dosage: Typical dosages range from 500mg to 2 grams per day, depending on the desired benefits and individual needs

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