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The peptide enhances expression of key transcription factors including Lhx2 and Sox9 essential for hair follicle stem cell maintenance and activation while modulating Wnt/-catenin signalinga critical pathway for hair follicle morphogenesis and cyclingwith treated follicles showing enhanced -catenin nuclear localization and increased Wnt target gene expression

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Tirzepatide has a lower rate of nausea and vomiting compared to Semaglutide, likely due to the presence of GIP, which helps mitigate gastrointestinal discomfort

Moreover, enzymes involved in the antioxidant pathway (for instance, thioredoxin reductase) and GSH-producing pathway (for instance, glutathione synthetase and heterodisulfide reductase subunit C) were altered when gr was deleted or overexpressed in A