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Non-neuronal cell types, including microglia and oligodendrocytes (OLIG), demonstrate unique methylation profiles

Oleic acid exerts direct and indirect suppression of NF-B, a key inflammatory transcription factor, and reduces NLRP3 inflammasome activation, thereby limiting production of pro-inflammatory cytokines IL-1 and IL-18 [70]

7 Possible Mechanisms of Action In preclinical data, BPC-157 has been proposed to have multiple actions on several core pathways

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NRF2 is involved in regulating programmed functions in response to oxidative stimuli, such as autophagy, inflammasome assembly, endoplasmic reticulum stress/unfolded protein response, mitochondrial biogenesis, and stem cell regulation