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In aerobic microorganisms, O- demethylation is carried out by enzymes that can be divided into three groups: Rieske oxygenases (RO), cytochromes P450 (P450s), and tetrahydrofolate (THF)-dependent demethylases [26]

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These circadian clock genes significantly influence the adaptive ROS threshold across different circadian phases

HA-based systems have emerged as highly promising tools in a wide spectrum of clinical applications due to their biocompatibility, biodegradability, and ability to interact with specific cellular receptors such as CD44, enabling both regenerative and therapeutic benefits across diverse medical fields

We found CHAC1 expression is increased under multiple muscle wasting conditions in animal models, including fasting, cancer cachexia, and chemotherapy