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Clinical interventions targeting NE, such as NE inhibitors like sivelestat, are being explored for their potential to mitigate lung damage and improve outcomes in COVID-19-induced ARDS (128)

M1 macrophages exhibit dysregulated iron metabolism, with increased expression of hepcidin (Hamp) and ferritin heavy/light chains (FTH/FTL), and reduced expression of ferroportin (FPN) and IRP1/2 (88)