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[DOI] [Google Scholar] 819.Irwin J.B., Baldwin A.L., Stenberg V.I

From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders

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After inducing expression of GFP-tagged wild-type or mutant FUS/TLS in HeLa cells, endogenous FUS/TLS was reduced by transfection of an siRNA targeting a sequence in the 3 untranslated region of the endogenous FUS/TLS gene, but missing from transgenes (Fig

Next, we measured the cristae width of hundreds of mitochondria and determined that rapamycin-treated CAR T cell products had significantly looser mitochondrial cristae, which is consistent with their less-activated metabolic state (Fig