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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

doi: 10.1038/s41598-021-93003-3 58 ZhangHKongWZhaoXXieYLuoDChenS

Hydroxocobalamin, when given for cyanide poisoning at the recommended dose of 5g, may cause a temporary reddish discolouration of the skin, plasma, urine, and mucous membranes

Peripheral artery disease Peripheral artery disease (PAD) is a complete or partial occlusion of the peripheral artery in the limb by an atherosclerosis plaque

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