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Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model

Concentration and Dosing Differences Each copper peptide type has different effective concentration ranges

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Peak purity analysis revealed a peak purity index for D-Nle-Tyr- Ile-NH-(CH 2 )5-CONH 2 of 0.95 and the internal standard of 0.94

Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction