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Alphs L, Benson C, Cheshire-Kinney K, et al

A minimum of 100 cells per group were analyzed using relative signal intensities or analyzed with the Incucyte 2022B software as the integrated intensity normalized to the phase area

This interpretation is also consistent with the clinical efficacy of liver transplantation, where replacement of the main site of TTR production reduces disease progression despite continued peripheral tissue expression of TTR

N Engl J Med 2024;392:12737

The aorta was then carefully dissected, the adventitial layer was meticulously removed using forceps, and the tissue was subsequently transferred to cell culture dishes under sterile conditions