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Abnormal trajectory: expanding redness beyond 3cm diameter, increasing warmth, new onset of pain after initial comfort, or lymphatic streaking (red lines extending from the site toward the trunk)

The COVID-19 pandemic, as highlighted by various epidemiological studies, exacerbated the global gap in PN management

The importance of Cat in the neoplastic scenarios has long been appreciated, as various studies have demonstrated that increased activity of this enzyme in tumour cells constitute a protection mechanism against cell death induced by reactive oxygen species (ROS), and that by inhibiting this enzyme, the neoplastic cells become once more vulnerable to this outcome [54], [55]

Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment

Vitamin B12 plays a vital role in red blood cell production, nerve function, and cellular energy