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In cosmetic science, this translates to an active that can intervene in both oxidative stress pathways and melanogenesis regulation, making it one of the few ingredients that offers dual antioxidant and brightening performance

Indeed, lead has been shown to cause gut microbiota dysbiosis and hepatic metabolic disorder in zebrafish (Xia et al., 2018a), and a 2020 study established that cadmium exposure altered the intestinal microbiota in freshwater crayfish ( Procambarus clarkia ) with regards to richness, diversity and composition, while also causing histological changes in the intestines (Zhang et al., 2020b)

Moreover, the assessment of MD adherence is influenced by cultural, socioeconomic, and lifestyle factors, and definitions of high adherence vary considerably across studies (209, 210)