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Intestinal oxidative stress associated with excessive ROS generation causes oxidative modifications to tight junction proteins leading to increased intestinal permeability, invasion of luminal bacteria, and gut dysbiosis

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The selenium therapy in coronary artery disease patients (SETCAP) study

In Europe, the European Food Safety Authority (EFSA) requires formal evaluation and approval of health claims under Regulation (EC) No 1924/2006, while nanoformulations or novel delivery systems often fall under the Novel Food Regulation (EU 2015/2283), requiring comprehensive safety and toxicological data

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As such, investigating the impact of MAT2A inhibitors on the function of tumour-associated T cells may provide additional insight into how the efficacy of immune-checkpoint inhibitors could be improved