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Glia 62:13771391 McKenna MC, Tildon JT, Stevenson JH, Huang X (1996) New insights into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes

Epub 2017 Sep 25

It can be triggered by oxidant air pollutants and cigarette smoke and/or by endogenous reactive oxygen species (ROS) released from mitochondria and activated inflammatory, immune and epithelial cells in the airways, together with a reduction in endogenous antioxidants such as glutathione (GSH)

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First, there is an urgent need for region-specific treatment guidelines that emphasize the short-term use of corticosteroids followed by the transition to maintenance therapy [36]