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As mentioned above, decreased Nrf2 expression and protein levels, and concomitantly, a lower activity of antioxidant defense, are found in tissues from COPD patients

Gutierrez-Uzquiza from Autonomous Community of Madrid (CAM)

Higher levels of cGAS micronuclei were observed in BRCA2 -deficient cells, while cGAS-STING was considered responsible for IRF3 phosphorylation

Signal Transduct Target Ther 2:17023 Oh S, Bournique E, Bowen D et al (2021) Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

Since proteasomal degradation typically yields small peptides ranging from 6-10 residues 16,17 , the proteasome is unlikely to generate the observed degradation products