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Description

SIRT2-dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases

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First, excessive Fe 2+ enhances the Fenton reaction and produces oxhydryl radicals

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In response to ROS, NE leaves the azurophilic granule and translocates to the nucleus, where it initiates relaxation and decondensation of chromatin by cleaving histones, a crucial event in NET formation

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Jandial R, Neman J, Lim PP, Tamae D, Kowolik CM, Wuenschell GE, et al

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