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While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

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Awareness of liver disease was assessed based on a positive response to ever told you had any liver condition on the Medical Conditions Questionnaire

Hence, we reasoned that Cys uptake may counteract ferroptosis not only through the well-established CysGSHGPX4 axis but also by enabling biosynthesis of S 0 species

The authors would like to thank Dr Pueschel for reviewing a draft of the article and for his helpful suggestions