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Secondary hyperuricemia is also seen in individuals with myeloproliferative disorders undergoing therapy where there is excess cellular turnover (cell lysis leads to an accumulation of nucleotides) or in cases of Von Gierke disease or fructose intolerance, which increases substrate for PRPP synthesis

doi: 10.1172/JCI178722 2 MengXLayhadiJAKeaneSTCartwrightNJKDurhamSRShamjiMH

PQQ, a vitamin-like compound found in fruits and vegetables, is a powerful antioxidant that protects nerve cells, supports the mitochondria, enhances memory, and lowers inflammation

doi:10.3390/biology9090252 13

Gene editing for cardiovascular and metabolic diseases Existing or emerging therapies targeting genetic pathways Gene editing is a different approach to genetic medicine that holds great promise for the treatment of cardiovascular and metabolic diseases