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For the p.L136P mutation identified in this pedigree, Leucine was replaced by Proline in exon 3, which is the most evolutionary conserved part of the CBS enzyme

Accordingly, FtMt dysfunction promotes mitochondrial iron overload and excessive mtROS accumulation, thereby increasing cellular susceptibility to ferroptosis [83]

Application of regulatory cell death in cancer: based on targeted therapy and immunotherapy

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However, what can be inferred from the available data is that there is an interplay between H 2 S and NO/cGMP in CC and that the on/off switching of signaling may be reciprocally regulated and influenced by testosterone (174)