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Esmeralda, The Orchid Society of Eastern Himalaya & The Directorate of Cinchona & Other Medicinal Plants 1, 7280 (2015)

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In contrast to the IVW approach which sets the intercept term to zero, the introduction of the aforementioned parameter in the MR-Egger framework enables assessment of pleiotropic effects that may be distributed independently from those of instrumental variables (IVs) on outcomes through exposures

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Conflicting findings exist [e.g., alpha-linolenic acid (ALA) has no antidepressant effect in some human cohorts]