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2026;e10628

Unick, J

Second, the hypoxic environment of the periodontal pocket directly upregulates expression of the fatty acid transporter CD36 via HIF-1, increasing cellular uptake of extracellular fatty acids and providing a more abundant substrate for ACSL4 (25, 26)

Broadly speaking, inflammatory M1 macrophages rely predominantly on glycolysis and glucose-driven pathways while reparative M2 macrophages predominantly utilize FAO and drive OXPHOS