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Description

In relapsed or refractory myeloma (R/R MM) patients, the CD38 expression levels are relatively high in NK cells, regulatory B cells (Bregs), Tregs and myeloid-derived suppressor cells (MDSCs) compared with CD8 + and CD4 + T cells, indicating that CD38 is involved in providing the immunosuppressive environment for tumor growth [19]

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Research has shown that High-dose intravenous methylprednisolone, commonly used in MS management, can lead to decreased levels of vitamin B12 and folate in the cerebrospinal fluid and serum of MS patients [147]

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Furthermore, LL-37 can neutralize endotoxins, reducing inflammation caused by microbial products (Davidson et al., 2004)

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