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Cell membrane PUFAs can undergo peroxidation reactions via LOXs, iron-containing enzymes that also induce cell ferroptosis

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doi: 10.1097/HEP.0000000000001007 120 RudmikLMaglioccoA

Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis