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Moreover, pharmacokinetic evaluations reveal that AOD 9604 has a short plasma half-life of about three to four minutes intravenously and slower absorption when administered orally

114 Further complicating the relationship between metformin and gut microbiota is a recent study on mice that found that some of the antidiabetic effects of metformin may be mediated by positive alterations to the microbiome

And I think it does raise a few important questions and hopefully some answers as well

On a cellular level, MOTS-c engages with known longevity pathways