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Mutations in GBA Promote Toxic Conversion of -Synuclein Mutations in the GBA gene, which encodes the lysosomal enzyme GCase, have been shown to be strongly associated with PD and are the most common risk factor for PD and DLB, found in 25% of all DLB and greater than 10% of PD patients (Clark et al., 2010

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Its protective effects against oxidative damage, achieved by inhibiting iron-catalyzed Fenton reactions, were reported as early as the late twentieth century [368]