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This accessible and scalable approach provides a reproducible baseline for studying fibroblast activation and supports the use of DOE as a powerful strategy for defining microenvironmental conditions that regulate fibroblast behavior in vitro

In summary, therapeutic phase II or III clinical trials investigating the efficacy of pharmacological or non-pharmacological treatment of CIPN, among patients treated with oxaliplatin, published in English, were considered for this review

Group II included five genes: family with Ras association (RalGDS/AF-6) domain family member 2 ( Rassf2 ), Gm15716 , protein chibby homolog 1 ( Cby1 ), sequence similarity 43, member A ( Fam43a ) and sorting nexin 29 ( Snx29 )

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