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Knocking down ICA69 reversed GPX4 inhibition, attenuated intracellular ferroptosis production and improved mouse survival and cardiac function [93]

Nielsen RL, Wolthers BO, Helenius M, Albertsen BK, Clemmensen L, Nielsen K, et al

However, besides MS-based compound characterization with additional derivatization experiments, no structure elucidation of metabolites has been performed (Ivanova et al

81 Besides, SAM can participate in lipid synthesis through the phosphotidylethanolamine N-methyltransferase pathway, which is essential for forming very-low-density lipoproteins (VLDLs)