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Excess iron ions disrupt the electron transport chain and reduce ATP synthesis in the mitochondria

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Telomeres are the protective caps at the ends of chromosomes that shorten with each cell division critically short telomeres trigger cellular senescence, the state in which cells stop dividing and start secreting inflammatory signals that degrade surrounding tissue

Increased expression of VEGF stimulates angiogenesis, acting on dopamine D1 receptors, and may cause, among other things, dyskinesia, a major side effect of L-DOPA, which may further reduce the quality of life of PD patients under L-DOPA medication (Veith and Henderson 2019) Increased VEGF expression has been also documented in astrocytes, endothelial cells (ECs), and monocytes of MS patients, potentially contributing to BBB permeability and the onset of MS

Published research on combined administration is minimal