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In the last years, several preclinical studies and clinical trials have been effectuated using different GSK-3 inhibitors, actually with few encouraging results

The distinct actions of Myo-Ins and Mdivi-1 indicate that the Myo-Insdependent potentiation of ATP-mediated Ca signalling does not primarily depend on mitochondrial fission inhibition, consistent with a mechanism acting at the level of PIP metabolism or IP-mediated signalling, rather than through changes in mitochondrial structure

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Conversely, when transsulfuration is stressed, methylation capacity may also be affected

Topical antioxidants such as CE ferulic acid can be considered in selected cases when patients understand the role of sunscreens & primary pigment correctors