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Description

The Phe residue that moves between the open and closed conformation is displayed in orange and the residue forming a hydrogen bond with the ligand is displayed in green

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Other studies have shown that enhancing SIRT1 activity using pharmacological agents can reduce different types of hearing loss, indicating that SIRT1 is a promising target for hearing protection [22, 23]

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In contrast to its neuroprotective role, CHAC1 promotes organ injury in other contexts primarily through ferroptosis regulation

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