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doi: 10.5005/jcdp-5-2-1 78 AvelloMSuwalskyM

The search included articles published between 2010 and 2025, using keywords: Parkinsons disease, -synuclein, dopaminergic degeneration, ferroptosis, deep brain stimulation, stem cell therapy, and AI in PD diagnosis. Results: The review highlights a multifactorial etiology involving -synuclein pathology, oxidative stress, mitochondrial dysfunction, genetic mutations (SNCA, LRRK2, VPS35), environmental toxins, and gut dysbiosis

Meanwhile, DDM has low immunogenicity and does not cause severe inflammatory reactions in the host [17], making it an ideal choice for bone graft substitute

Unlike superficial peels, it penetrates deeper into the skin layers to promote cellular turnover, helping to reveal fresher, smoother, and healthier-looking skin beneath the surface

Further, decrease in levels of B 12 demonstrated in patient with multiple sclerosis (Miller et al., 2005)