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(Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) are more correctly regarded as measures of serum creatinine and/or cystatin C that have been adjusted for age, gender, and race, then factored to produce a numerical quantity similar to a measured GFR

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Houston M, Harper K

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Ning, X.-H

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The presence of an MTHFR polymorphism should therefore be viewed as one factor influencing methylation efficiency rather than evidence that folic acid is ineffective

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