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When researchers gave hyperuricemic mice quercetin doses of 25, 50, and 100 mg/kg, their blood urate levels dropped while urate excretion went up [12]

Risks and Side Effects Cortisone Injections: While cortisone is generally safe for occasional use, repeated injections can have side effects, including: Tissue degeneration (especially in tendons and cartilage) Joint infection (rare but serious) Elevated blood sugar (in diabetic patients) Skin discoloration or thinning Repeated cortisone use has been linked with weakened tendons , potentially leading to ruptures

This leads to damage to tissue cells, including vascular ECs (Incalza et al., 2018), adipocytes (Furukawa et al., 2004), and pancreatic -cells (Gerber and Rutter, 2017)

10.1039/c0em00056f 63 IslamM

The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles