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Molecules of free radicals with unpaired electrons in their outer shells, including superoxide radical (O 2 - ), hydrogen peroxide (H 2 O 2 ), and the hydroxyl radical (HO) produced in autoxidation reactions are important components of ROS in the cell [8]

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For example, nerve biopsies from rodents and patients administered cisplatin (Dougherty et al., 2004), paclitaxel, oxaliplatin, vincristine, and bortezomib show similar morphological changes (loss of IENFs) even though these compounds have different neurotoxic targets (Flatters and Bennett, 2006

A decisive and rate-limiting step is the formation of a SM Qa-SNARE R-SNARE complex that provides the template for the binding of the other two SNARE motifs (Baker et al., 2015)