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Metabolomic biomarkers of inflammatory disease Metabolomic analysis has become not only essential for drug development [153] and understanding modes of action such as the recent metabolomic profiling of TCA cycle-derived metabolites in macrophages upon glucocorticoid (GC) treatment, which identified itaconate as a driver of anti-inflammatory effects of GC treatment [154]

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GSSG levels were determined using a microplate reader at 450 nm and expressed as ng/mg wet tissue (MyBiosource MBS749109)

It is used in the treatment of Acute Intermittent Porphyric patients as a ribonucleic acid interference therapy which works by reducing the production of heme precursors and aminolevulinic acid synthase 1 messenger Ribonucleic Acid levels in the liver, which causes symptoms